Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis.

Cell death and differentiation - 1 Mar 2005

D'Costa A M, Denning M F

Abstract excerpt

Keratinocyte apoptosis induced by UV radiation is a major protective mechanism from skin photocarcinogenesis. The induction of apoptosis by UV radiation, as well as a variety of genotoxic stimuli, involves the activation of PKC-delta by caspase-3-mediated cleavage in its hinge region, thus generating a constitutively active catalytic fragment. To determine the role of PKC-delta cleavage in UV apoptosis signaling,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to Caspase Inhibitors
Share to Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochromes c

Share to Keratinocytes

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Protein Kinase C

Share to Protein Kinase C-delta

Source

Identifiers

PMID: 15618968
DOI: 10.1038/sj.cdd.4401558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis.PMID 15618968Read ↗

Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes.Semantic proximity Read ↗

Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based PhototherapySemantic proximity Read ↗

Apoptosis and efficient repair of DNA damage protect human keratinocytes against UVBSemantic proximity Read ↗

Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis.Semantic proximity Read ↗

Molecular aspects of ultraviolet radiation-induced apoptosis in the skin.Semantic proximity Read ↗

p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation.Semantic proximity Read ↗

PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells.Semantic proximity Read ↗

Retinoic Acid Increases the Expression of p53 and Proapoptotic Caspases and Sensitizes Keratinocytes to ApoptosisSemantic proximity Read ↗

Terminal differentiation of human epidermal keratinocytes involves mitochondria- and caspase-dependent cell death pathwaySemantic proximity Read ↗

Involvement of proteolytic activation of PKCdelta in cisplatin-induced apoptosis in human small cell lung cancer H69 cells.Semantic proximity Read ↗

Fas-independent apoptosis induced by UVC in p53-mutated human epithelial tumor A431 cells through activation of caspase-8 and JNK/SAPK.Semantic proximity Read ↗

Apoptosis, the only cell death pathway that can be measured in human diploid dermal fibroblasts following lethal UVB irradiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.