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Article

Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus.

Genes and immunity - 1 Apr 2009

Delgado-Vega Angélica M, Abelson Anna-Karin, Sánchez Elena, Witte Torsten, D'Alfonso Sandra, Galeazzi Mauro, Jiménez-Alonso Juan, Pons-Estel Bernardo A, Martin Javier, Alarcón-Riquelme Marta E

Abstract excerpt

The tumor necrosis factor ligand superfamily member 4 gene (TNFSF4) encodes the OX40 ligand (OX40L), a costimulatory molecule involved in T-cell activation. A recent study demonstrated the association of TNFSF4 haplotypes located in the upstream region with risk for or protection from systemic lupus erythematosus (SLE). To replicate this association, five single nucleotide polymorphisms (SNPs) tagging the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19092840
DOI: 10.1038/gene.2008.95
PMCID: PMC3867640

Genes

TNFSF4

Provenance

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Related research

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Research trail→

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Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus.PMID 19092840Read ↗

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort.Semantic proximity Read ↗

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis.Semantic proximity Read ↗

The molecular genetic basis of the association of TNFSF4 with SLESemantic proximity Read ↗

A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population.Semantic proximity Read ↗

TNFSF4 is a risk factor to systemic lupus erythematosus in a Latin American population.Semantic proximity Read ↗

Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.Semantic proximity Read ↗

Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

Haplotype structure of TNFRSF5-TNFSF5 (CD40-CD40L) and association analysis in systemic lupus erythematosus.Semantic proximity Read ↗

Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis.Semantic proximity Read ↗

Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

The functional TNFAIP3 rs2230926T/G (Phe127Cys) variant confers risk to systemic lupus erythematosus in a Latin American population.Semantic proximity Read ↗

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