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Article

A premature termination codon mutation at the C terminus of foamy virus Gag downregulates the levels of spliced pol mRNA.

Journal of virology - 1 Feb 2008

Lee Eun-Gyung, Kuppers Daniel, Horn Megan, Roy Jacqueline, May Cynthia, Linial Maxine L

Abstract excerpt

Foamy viruses (FV) comprise a subfamily of retroviruses. Orthoretroviruses, such as human immunodeficiency virus type 1, synthesize Gag and Pol from unspliced genomic RNA. However, FV Pol is expressed from a spliced mRNA independently of Gag. FV pol splicing uses a 3' splice site located at the 3' end of gag, resulting in a shared exon between gag and pol. Previously, our laboratory showed that C-terminal Gag...

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Identifiers

PMID: 18057244
DOI: 10.1128/JVI.00990-07
PMCID: PMC2258731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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