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Article

Role of the foamy virus Pol cleavage site in viral replication.

Journal of virology - 1 May 2007

Roy Jacqueline, Linial Maxine L

Abstract excerpt

Foamy virus Pol precursor protein processing by the viral protease occurs at only one site, releasing a protease-reverse transcriptase and an integrase protein. To examine whether the cleavage of the Pol precursor protein is necessary for enzymatic activities and efficient viral replication, several mutations were generated around the cleavage site. All cleavage site mutants synthesize wild-type levels of Pol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17344283
DOI: 10.1128/JVI.00104-07
PMCID: PMC1900213

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