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Human Foamy Virus Replication: A Pathway Distinct from That of Retroviruses and Hepadnaviruses

15 Mar 1996

Abstract excerpt

Human foamy virus (HFV) is the prototype of the Spumavirus genus of Retroviridae. In all other retroviruses, the pol gene products, including reverse transcriptase, are synthesized as Gag-Pol fusion proteins and are cleaved to functional enzymes during viral budding or release. In contrast, the Pol protein of HFV is translated from a spliced messenger RNA and lacks Gag domains. Infectious HFV particles contain...

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PMID: 8599113
DOI: 10.1126/science.271.5255.1579

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