Article
Population-specific evolution of HIV Gag epitopes in genetically diverged patients.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2013
Abidi Syed H, Shahid Aniqa, Lakhani Laila S, Khanani Muhammad R, Ojwang Peter, Okinda Nancy, Shah Reena, Abbas Farhat, Rowland-Jones Sarah, Ali Syed
Abstract excerpt
BACKGROUND: Under the host selection pressure HIV evolves rapidly to override crucial steps in the antigen presentation pathway. This allows the virus to escape binding and recognition by cytotoxic T lymphocytes. Selection pressures on HIV can be unique depending on the immunogenetics of host populations. It is therefore logical to hypothesize that the virus evolving in a given population will carry signature...
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