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Article

c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation.

Cancer research - 1 Dec 2007

Ravitz Michael J, Chen Li, Lynch Mary, Schmidt Emmett V

Abstract excerpt

The c-myc oncogene plays a key role in cellular growth control, and translation initiation factors are among the transcriptional targets of Myc. Here, we describe a defect in translation initiation control in myc-null cells due to alterations in the mammalian target of rapamycin (mTOR) pathway. Myc loss increased sensitivity to dominant inhibition of eukaryotic translation initiation factor 4E function. Polysomal...

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Source

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Identifiers

PMID: 18056446
DOI: 10.1158/0008-5472.CAN-06-4351
PMCID: PMC3022657

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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