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Article

Tsc2 coordinates neuroprogenitor differentiation

14 Nov 2023

Abstract excerpt

Neural stem cells (NSCs) of the ventricular-subventricular zone (V-SVZ) generate numerous cell types. The uncoupling of mRNA transcript availability and translation occurs during the progression from stem to differentiated states. The mTORC1 kinase pathway acutely controls proteins that regulate mRNA translation. Inhibiting mTORC1 during differentiation is hypothesized to be critical for brain development since...

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PMID: 38107199
DOI: 10.1016/j.isci.2023.108442

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