Article

<i>TSC2</i> loss in neural progenitor cells suppresses translation of ASD/NDD-associated transcripts in an mTORC1- and MNK1/2-reversible fashion

2024-06-04

Abstract excerpt

<h4>SUMMARY</h4> Tuberous sclerosis complex (TSC) is an inherited neurodevelopmental disorder (NDD) with frequent manifestations of epilepsy and autism spectrum disorder (ASD). TSC is caused by inactivating mutations in TSC1 or TSC2 tumor suppressor genes, with encoded proteins hamartin (TSC1) and tuberin (TSC2) forming a functional complex inhibiting mechanistic target of rapamycin complex 1 (mTORC1) signaling...

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Literature Corpus work: 9880fb5d-4226-56ae-80c3-d4aa7f8d1d6f
DOI: 10.1101/2024.06.04.597393

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