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Article

Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via <i>slug</i> induction and actin remodeling

3 Dec 2007

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a critical process occurring during embryonic development and in fibrosis and tumor progression. Dissociation of cell-cell contacts and remodeling of the actin cytoskeleton are major events of the EMT. Here, we show that myocardin-related transcription factors (MRTFs; also known as MAL and MKL) are critical mediators of transforming growth factor beta (TGF-beta)...

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PMID: 18056415
DOI: 10.1083/jcb.200708174

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