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Article

SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance.

The pharmacogenomics journal - 1 Dec 2010

Edvardsen H, Brunsvig P F, Solvang H, Tsalenko A, Andersen A, Syvanen A-C, Yakhini Z, Børresen-Dale A-L, Olsen H, Aamdal S, Kristensen V N

Abstract excerpt

The dose of docetaxel is currently calculated based on body surface area and does not reflect the pharmacokinetic, metabolic potential or genetic background of the patients. The influence of genetic variation on the clearance of docetaxel was analysed in a two-stage analysis. In step one, 583 sin...

Read the complete abstract on PubMed

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20157331
DOI: 10.1038/tpj.2010.6

Genes

GSTA4
PRDX4
TGFBR2
XPC
BCL2
DPYD
EGF
EGFR
EPHX1
IGF2
MAPK7
NDUFB4
TGFBR3
TNFAIP2
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20157331-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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