Article
A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder.
Human molecular genetics - 1 Mar 2008
Wendland Jens R, Moya Pablo R, Kruse Matthew R, Ren-Patterson Renee F, Jensen Catherine L, Timpano Kiara R, Murphy Dennis L
Abstract excerpt
Obsessive-compulsive disorder (OCD) is a disabling neuropsychiatric illness with strong segregation data indicative of major genetic contributions. Association analyses of common functional variants of the serotonin transporter gene (SLC6A4), a long-standing OCD candidate, have so far been inconsistent. Here, we set out to investigate the role of additional functional SLC6A4 loci in OCD. We describe a common,...
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