Article
Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2011
Samuels Jack, Wang Ying, Riddle Mark A, Greenberg Benjamin D, Fyer Abby J, McCracken James T, Rauch Scott L, Murphy Dennis L, Grados Marco A, Knowles James A, Piacentini John, Cullen Bernadette, Bienvenu O Joseph, Rasmussen Steven A, Geller Daniel, Pauls David L, Liang Kung-Yee, Shugart Yin Y, Nestadt Gerald
Abstract excerpt
SLC1A1 encodes a neuronal glutamate transporter and is a promising candidate gene for obsessive-compulsive disorder (OCD). Several independent research groups have reported significant associations between OCD and single nucleotide polymorphisms (SNPs) in this gene. Previously, we evaluated 13 SNPs in, or near, SLC1A1 and reported a strong association signal with rs301443, a SNP 7.5 kb downstream of the gene...
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