Article
The contribution of mitochondrial dysfunction to a gene-environment model of Guamanian ALS and PD.
Mitochondrion - 1 Mar 2008
Lynch Daniel, Wanglund Christian, Spathis Rita, Chan Chim W, Reiff Dana M, Lum J Koji, Garruto Ralph M
Abstract excerpt
Scientific investigations of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) of Guam have implicated genetic and environmental risk factors in their etiology. Using brain tissue, we investigated mitochondrial dysfunction and report a higher frequency of somatic mutations in the light strand promoter (LSP) of the mitochondrial control region in Guam ALS and PD patients than in Guam controls,...
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