Article
Inherited and somatic mitochondrial DNA mutations in Guam amyotrophic lateral sclerosis and parkinsonism-dementia.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Oct 2011
Reiff Dana M, Spathis Rita, Chan Chim W, Vilar Miguel G, Sankaranarayanan Krithivasan, Lynch Daniel, Ehrlich Emily, Kerath Samantha, Chowdhury Risana, Robinowitz Leah, Koji Lum J, Garruto Ralph M
Abstract excerpt
There is increasing evidence for mitochondrial dysfunction in neurodegenerative disorders, although the exact role of mitochondrial DNA (mtDNA) mutations in this process is unresolved. We investigated inherited and somatic mtDNA substitutions and deletions in Guam amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD). Hypervariable segment 1 sequences of Chamorro mtDNA revealed that the odds ratio of...
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