Article
Oxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice.
Pharmacology, biochemistry, and behavior - 1 Oct 1991
Jodogne C, Tirelli E, Klingbiel P, Legros J J
Abstract excerpt
Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2...
Topics
- Animals
- Body Temperature
- Drug Tolerance
- Ethanol
- Male
- Mice
- Motor Activity
- Muscle Relaxants, Central
- Muscle Tonus
- Oxytocin
- Phenotype