Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics and ethanol tolerance.

Drug and alcohol dependence - 1 Jan 2000

McClearn G E, Anderson S M

Abstract excerpt

This paper reviews some of the research on genetic bases of individual differences in ethanol tolerance of mice conducted at the Institute for Behavioral Genetics and at its predecessor laboratory at the University of California, Berkeley. Tolerance is, of course, a complex concept. Theoretical distinctions are made between tachyphylaxis and more slowly acquired tolerance and between dispositional and tissue...

Topics

Alcohol Drinking
Alcoholism
Animals
Drug Tolerance
Ethanol
Genetic Variation
Genotype
Humans
Mice
Mice, Inbred Strains
Phenotype
Selection, Genetic
Sleep

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Social Environment

Substance Withdrawal Syndrome

Source

Identifiers

PMID: 574446
DOI: 10.1016/0376-8716(79)90041-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-574446-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics and ethanol tolerance.PMID 574446Read ↗

Genetic-environment analysis of sensitivity and acute tolerance to ethanol in mice.Semantic proximity Read ↗

Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines.Semantic proximity Read ↗

Response to selection for sensitivity to ethanol hypothermia: genetic analyses.Semantic proximity Read ↗

Large genetic analysis of alcohol resistance and tolerance reveals an inverse correlation and suggests ‘true’ tolerance mutantsSemantic proximity Read ↗

Tolerance to ethanol hypothermia in HOT and COLD mice.Semantic proximity Read ↗

Genetic matters: thirty years of progress using mouse models in nicotinic research.Semantic proximity Read ↗

Tolerance in Drosophila.Semantic proximity Read ↗

Response to selection for ethanol-induced locomotor activation: genetic analyses and selection response characterization.Semantic proximity Read ↗

Behavior genetics of drug sensitization.Semantic proximity Read ↗

Issues surrounding the assessment of the genetic determinants of drugs as reinforcing stimuli.Semantic proximity Read ↗

Genetics and the evolution of the anesthetic response.Semantic proximity Read ↗

Large analysis of genetic manipulations reveals an inverse correlation between initial alcohol resistance and rapid tolerance phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.