Article
Comprehensive analysis of loss of heterozygosity events in glioblastoma using the 100K SNP mapping arrays and comparison with copy number abnormalities defined by BAC array comparative genomic hybridization.
Genes, chromosomes & cancer - 1 Mar 2008
Lo Ken C, Bailey Dione, Burkhardt Tania, Gardina Paul, Turpaz Yaron, Cowell John K
Abstract excerpt
We have undertaken an extensive high-resolution analysis of loss of heterozygosity (LOH) in 30 high grade gliomas using the Affymetrix 100K SNP mapping array. Only 70% of LOH events were accompanied by a copy number loss (CNA(loss)), and of the other 30%, the distal region of 17p preferentially showed copy number neutral (CNN)-associated LOH. Combined analysis of CNA(loss) and LOH using MergeLevels analysis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.