Article
CHROMSCAN: genome-wide association using a linkage disequilibrium map.
Journal of human genetics - 1 Jan 2008
Collins Andrew, Lau Winston
Abstract excerpt
CHROMSCAN implements a composite likelihood model for the analysis of association data. Disease-gene localisation is on a linkage disequilibrium unit (LDU) map, and locations and standard errors, for putatively causal polymorphisms, are determined by the programme. Distortions of the probability distribution created by auto-correlation are avoided by implementation of a permutation test. We evaluated the relative...
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