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Article

Mouse model of heterotaxy with single ventricle spectrum of cardiac anomalies.

Pediatric research - 1 Jan 2008

Aune Christine N, Chatterjee Bishwanath, Zhao Xiao-Qing, Francis Richard, Bracero Luciann, Yu Qing, Rosenthal Julie, Leatherbury Linda, Lo Cecilia W

Abstract excerpt

Heterotaxy arises from a failure of the embryo to establish normal left-right asymmetry and is known to affect 3% of infants with congenital heart disease. A recessive mutation causing heterotaxy was recovered in a mouse mutagenesis screen focused on congenital heart defects. Homozygote mutants exhibit abnormal situs in the thoracic and abdominal cavities. Dextrocardia, levocardia, or mesocardia was seen together...

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Identifiers

PMID: 18043505
DOI: 10.1203/PDR.0b013e31815b6926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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