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Article

Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas

21 Feb 2007

Abstract excerpt

Gastrointestinal stromal tumor (GIST) has emerged as a clinically distinct type of sarcoma with frequent overexpression and mutation of the c-Kit oncogene and a favorable response to imatinib mesylate [also known as STI571 (Gleevec)] therapy. However, a significant diagnostic challenge remains in the differentiation of GIST from leiomyosarcomas (LMSs). To improve on the diagnostic evaluation and to complement the...

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PMID: 17360660
DOI: 10.1073/pnas.0611373104

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