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Targeting ErbB receptor signaling: A pan-ErbB approach to cancer

1 Oct 2004

Abstract excerpt

The ErbB receptors are localized to the cell membrane where they are activated by ligand to trigger a network of signaling pathways. In some cancer cells, dysregulation of ErbB-mediated signaling confers a growth advantage, resulting in cellular transformation and increased metastatic potential. Several agents that inhibit individual ErbB receptors have recently been approved for the treatment of human...

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PMID: 15486201
DOI: 10.1158/1535-7163.1335.3.10

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