A pseudouridine synthase required for the formation of two universally conserved pseudouridines in ribosomal RNA is essential for normal growth of Escherichia coli.

doi:10.1017/s1355838298981146

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Article

A pseudouridine synthase required for the formation of two universally conserved pseudouridines in ribosomal RNA is essential for normal growth of Escherichia coli.

RNA (New York, N.Y.) - 1 Nov 1998

Raychaudhuri S, Conrad J, Hall B G, Ofengand J

Abstract excerpt

Escherichia coli rRNA contains 10 pseudouridines of unknown function. They are made by synthases, each of which is specific for one or more pseudouridines. Here we show that the sfhB (yfil) ORF of E. coli is a pseudouridine synthase gene by cloning, protein overexpression, and reaction in vitro w...

Topics

Amino Acid Sequence
Base Sequence
Cell Division
Cloning, Molecular
Escherichia coli
Escherichia coli Proteins
Genes, Bacterial
Genes, Essential
Genetic Complementation Test
Hydro-Lyases
Intramolecular Transferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis, Insertional

Nucleic Acid Conformation

Phenotype

Polymerase Chain Reaction

Pseudouridine

RNA, Bacterial

Source

Open in PubMed Open full text

Identifiers

PMID: 9814761
DOI: 10.1017/s1355838298981146
PMCID: PMC1369713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9814761-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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