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Article

Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization.

ACS chemical neuroscience - 21 Nov 2012

Gessel Megan Murray, Bernstein Summer, Kemper Martin, Teplow David B, Bowers Michael T

Abstract excerpt

Although most cases of Alzheimer's disease (AD) are sporadic, ∼5% of cases are genetic in origin. These cases, known as familial Alzheimer's disease (FAD), are caused by mutations that alter the rate of production or the primary structure of the amyloid β-protein (Aβ). Changes in the primary structure of Aβ alter the peptide's assembly and toxic activity. Recently, a primary working hypothesis for AD has evolved...

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Identifiers

PMID: 23173071
DOI: 10.1021/cn300050d
PMCID: PMC3503339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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