Article
Lymphotoxin 252A>G polymorphism is common and associates with myocardial infarction in patients with rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Nov 2008
Panoulas V F, Nikas S N, Smith J P, Douglas K M J, Nightingale P, Milionis H J, Treharne G J, Toms T E, Kita M D, Kitas G D
Abstract excerpt
OBJECTIVE: Cardiovascular disease (CVD) is more prevalent and more likely to lead to death in patients with rheumatoid arthritis (RA). Single nucleotide polymorphisms of the genes for lymphotoxin-A (LT-A) and its regulatory protein galectin-2 (LGALS2) have been implicated as genetic risk factors for acute cardiovascular events in the general population: we hypothesised that their risk alleles/genotypes (a) may be...
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