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Article

Lymphotoxin-alpha gene 252G allelic variant is a risk factor for large-vessel-associated ischemic stroke.

Journal of molecular neuroscience : MN - 1 Jan 2005

Szolnoki Zoltán, Havasi Viktória, Talián Gábor, Bene Judit, Komlósi Katalin, Somogyvári Ferenc, Kondacs András, Szabó Mihály, Fodor Lajos, Bodor Anita, Melegh Béla

Abstract excerpt

A direct role of lymphotoxin-alpha (LTA) in promoting atherosclerotic plaque growth has been demonstrated recently. The different protein transcripts of the naturally occurring genetic variants of the LTA gene have been demonstrated to exhibit affected functions, and an allelic difference in binding to transcription factor(s) has also been suggested. The homozygous variant of LTA characterized by the intron 1...

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Source

Identifiers

PMID: 16186631
DOI: 10.1385/JMN:27:2:205

Genes

LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lymphotoxin-alpha gene 252G allelic variant is a risk factor for large-vessel-associated ischemic stroke.PMID 16186631Read ↗

A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.Semantic proximity Read ↗

Association between lymphotoxin alpha (-252 A/G and -804 C/A) gene polymorphisms and risk of stroke in North Indian population: a hospital-based case-control study.Semantic proximity Read ↗

Association between Lymphotoxin Alpha (-252G/A and -804C/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis.Semantic proximity Read ↗

Association of lymphotoxin-alpha gene polymorphisms (rs909253, rs1800683 and rs2229094) and risk of large-artery atherosclerosis stroke in Iranian population.Semantic proximity Read ↗

Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction.Semantic proximity Read ↗

Galectin-2 3279TT variant protects against the lymphotoxin-alpha 252GG genotype associated ischaemic stroke.Semantic proximity Read ↗

Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses.Semantic proximity Read ↗

Polymorphisms of the LTA gene may contribute to the risk of myocardial infarction: a meta-analysis.Semantic proximity Read ↗

Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.Semantic proximity Read ↗

Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations.Semantic proximity Read ↗

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