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Article

The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics.

Neuron - 21 Nov 2007

Lewcock Joseph W, Genoud Nicolas, Lettieri Karen, Pfaff Samuel L

Abstract excerpt

To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and wandered inefficiently at choice points within embryos, but paradoxically responded to guidance cues with normal sensitivity in vitro. We mapped the Magellan mutation...

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Identifiers

PMID: 18031680
DOI: 10.1016/j.neuron.2007.09.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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