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Article

The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons.

Genes & development - 15 Oct 2007

Bloom A Joseph, Miller Bradley R, Sanes Joshua R, DiAntonio Aaron

Abstract excerpt

Phr1 is the single well-conserved murine ortholog of the invertebrate ubiquitin ligase genes highwire (in Drosophila) and rpm-1 (in Caenorhabditis elegans). The function and mechanism of action of highwire and rpm-1 are similar--both cell-autonomously regulate synaptogenesis by down-regulating the ortholog of the mitogen-activated protein kinase kinase kinase dual leucine zipper kinase (MAPKKK DLK). Here, using a...

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Identifiers

PMID: 17901218
DOI: 10.1101/gad.1592107
PMCID: PMC2000324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons.PMID 17901218Read ↗

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Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.Semantic proximity Read ↗

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rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.Semantic proximity Read ↗

A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning.Semantic proximity Read ↗

Developmental Function of the PHR Protein RPM-1 Is Required for Learning in Caenorhabditis elegans.Semantic proximity Read ↗

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