Article

Determinants of Motor Neuron Functional Subtypes Important for Locomotor Speed

2022-12-26

Abstract excerpt

<h4>ABSTRACT</h4> Locomotion requires precise control of the strength and speed of muscle contraction and is achieved by recruiting functionally-distinct subtypes of motor neurons (MNs). MNs are essential to movement and differentially susceptible in disease, but little is known about how MNs acquire functional subtype-specific features during development. Using single-cell RNA profiling in embryonic and larval z...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0bbf4172-41b8-530a-9698-2f4b25d101ac
DOI: 10.1101/2022.12.23.521820

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Determinants of Motor Neuron Functional Subtypes Important for Locomotor SpeedDOI 10.1101/2022.12.23.521820Read

Single-cell transcriptomic analysis unveils spinal motor neuron subtype diversity underpinning the water-to-land transition in vertebratesSemantic proximity Read

A molecular atlas of adult <i>C. elegans</i> motor neurons reveals ancient diversity delineated by conserved transcription factor codesSemantic proximity Read

Single-cell transcriptomic analysis of the adult mouse spinal cordSemantic proximity Read

An ancient role for Collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron developmentSemantic proximity Read

Protocadherin-mediated cell repulsion controls the central topography and efferent projections of the abducens nucleusSemantic proximity Read

Single nuclei analyses reveal transcriptional profiles and marker genes for diverse supraspinal populationsSemantic proximity Read

Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity.Semantic proximity Read

Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations.Semantic proximity Read

An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron developmentSemantic proximity Read

Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.Semantic proximity Read

Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesisSemantic proximity Read

Genetic screens for genes controlling motor nerve-muscle development and interactions.Semantic proximity Read