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Article

FGF-10 plays an essential role in the growth of the fetal prostate.

Developmental biology - 1 Sept 2003

Donjacour Annemarie A, Thomson Axel A, Cunha Gerald R

Abstract excerpt

Induction and branching morphogenesis of the prostate are dependent on androgens, which act via the mesenchyme to induce prostatic epithelial development. One mechanism by which the mesenchyme may regulate the epithelium is through secreted growth factors such as FGF-10. We have examined the male reproductive tract of FGF-10(-/-) mice, and at birth, most of the male secondary sex organs were absent or atrophic,...

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Source

Identifiers

PMID: 12941620
DOI: 10.1016/s0012-1606(03)00250-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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