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Article

Lack of expression of EGF and TGF-alpha in the fetal mouse alters formation of prostatic epithelial buds and influences the response to TCDD.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2003

Abbott Barbara D, Lin Tien-Min, Rasmussen Nathan T, Albrecht Ralph M, Schmid Judith E, Peterson Richard E

Abstract excerpt

In utero, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure causes abnormal ventral, dorsolateral, and anterior prostate development in C57BL/6J mice. Androgens, mesenchymal-epithelial interactions, and growth factor expression all have roles in initiating and regulating development and growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14514962
DOI: 10.1093/toxsci/kfg238

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14514962-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Lack of expression of EGF and TGF-alpha in the fetal mouse alters formation of prostatic epithelial buds and influences the response to TCDD.PMID 14514962Read ↗

Estrogen signaling is not required for prostatic bud patterning or for its disruption by 2,3,7,8-tetrachlorodibenzo-p-dioxin.Semantic proximity Read ↗

EGF and TGF-alpha expression influence the developmental toxicity of TCDD: dose response and AhR phenotype in EGF, TGF-alpha, and EGF + TGF-alpha knockout mice.Semantic proximity Read ↗

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In Utero and Lactational TCDD Exposure Increases Susceptibility to Lower Urinary Tract Dysfunction in Adulthood.Semantic proximity Read ↗

The Role of Estrogens in Normal and Abnormal Development of the Prostate GlandSemantic proximity Read ↗

Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal development in mice.Semantic proximity Read ↗

Noggin is required for normal lobe patterning and ductal budding in the mouse prostate.Semantic proximity Read ↗

FGF-10 plays an essential role in the growth of the fetal prostate.Semantic proximity Read ↗

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