Article
The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata.
The British journal of dermatology - 1 Feb 2008
Betz R C, König K, Flaquer A, Redler S, Eigelshoven S, Kortüm A-K, Hanneken S, Hillmer A, Tüting T, Lambert J, De Weert J, Kruse R, Lutz G, Blaumeiser B, Nöthen M M
Abstract excerpt
BACKGROUND: The functional R620W (c.1858C>T) variant of the protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) has been associated with a variety of autoimmune disorders. A recent study has suggested that R620W also contributes to the severe form of alopecia areata (AA). OBJECTIVES: We sought to replicate the finding of an association between PTPN22 and severe AA. In addition, we wanted to study the effect...
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