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Article

Aberrant GITR expression on different T cell subsets and the regulation by glucocorticoid in systemic lupus erythematosus.

International journal of rheumatic diseases - 1 Feb 2016

Sun Jiafeng, Yu Ning, Li Xiangpei, Wang Li, Pan Yun, Li Xiaomei, Tao Jinhui, Chen Zhu, Wang Guosheng

Abstract excerpt

AIM: The dysfunction of T regulatory cells is important for the pathogenesis of systemic lupus erythematosus (SLE). Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is expressed at low levels on resting responder T lymphocytes (Tresps) and is up-regulated on T regulatory cells (Tregs) and activated T cells, diminishing suppressive activity of Tregs and/or leading to resistance...

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Source

Identifiers

PMID: 25293713
DOI: 10.1111/1756-185X.12451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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