Article
Functional T cell subpopulations responsible for hyposecretion of IL-2 in patients with systemic lupus erythematosus.
Clinical rheumatology - 1 Dec 1991
Hayama T, Kubo N, Ikeda E, Hashimoto H, Sawada S, Horie T
Abstract excerpt
The ability of T cells to secrete IL-2 in patients with systemic lupus erythematosus (SLE) was investigated. In patients with SLE, impaired IL-2 production by peripheral blood lymphocytes stimulated with mitogens is well known. In this paper, we report that purified T cells stimulated with mitogens, in the presence of Epstein-Barr virus transformed B cells (B-LCL) as an accessory cell, however, could secrete a...
Topics
- Adolescent
- Adult
- Blood Cells
- Cell Aggregation
- Female
- Humans
- Interleukin-2
- Lupus Erythematosus, Systemic
- Lymphocyte Subsets
- Middle Aged
- Phenotype
- T-Lymphocytes