Article
B cell hyperactivity is a function of T cell derived cytokines in systemic lupus erythematosus.
The Journal of rheumatology - 1 Nov 1993
al-Janadi M, Raziuddin S
Abstract excerpt
OBJECTIVE: T cell abnormalities and abnormal production of cytokines is a key event of B cell hyperactivity and antibody synthesis in systemic lupus erythematosus (SLE). We investigated T cell function and role of interleukin 4 (IL-4) and IL-6 in B cell induced Ig synthesis from SLE. METHODS: Phenotypes and expression of activation antigens on T cells and monocytes was determined by specific monoclonal antibodies...
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