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Article

Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2007

Tsao Ming-Sound, Aviel-Ronen Sarit, Ding Keyue, Lau Davina, Liu Ni, Sakurada Akira, Whitehead Marlo, Zhu Chang-Qi, Livingston Robert, Johnson David H, Rigas James, Seymour Lesley, Winton Timothy, Shepherd Frances A

Abstract excerpt

PURPOSE: p53 and RAS are multifunctional proteins that are critical to cell cycle regulation, apoptosis, cell survival, gene transcription, response to stress, and DNA repair. We have evaluated the prognostic and predictive value of p53 gene/protein aberrations using tumor samples from JBR.10, a North American phase III intergroup trial that randomly assigned 482 patients with completely resected stage IB and II...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18024870
DOI: 10.1200/JCO.2007.12.6953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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