Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma.

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Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2005

Burke Louise, Flieder Douglas B, Guinee Donald G, Brambilla Elizabeth, Freedman Andrew N, Bennett William P, Jones Raymond T, Borkowski Andrew, Caporaso Neil A, Fleming Marian, Trastek Victor, Pairolero Peter, Tazelaar Henry, Midthun David, Jett James R, Liotta Lance A, Travis William D, Harris Curtis C

Abstract excerpt

PURPOSE: Many studies have highlighted the aberrant expression and prognostic significance of individual proteins in either the Rb (particularly cyclin D1, p16INK4A, and pRb) or the p53 (p53 and p21Waf1) pathways in non-small cell lung cancer. We hypothesize that cumulative abnormalities within each and between these pathways would have significant prognostic potential regarding survival. EXPERIMENTAL DESIGN: Our...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 15671551

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