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[The importance of p53 and ras mutation as predictive markers for adjuvant chemotherapy in non-small-cell lung cancer].

Gan to kagaku ryoho. Cancer & chemotherapy - 1 Mar 2012

Hirai Yoshimitsu, Shimizu Yukio, Oura Shoji, Yoshimasu Tatsuya, Ota Fuminori, Nakamura Rie, Naito Koma, Nishiguchi Haruka, Hashimoto Sayoko, Okamura Yoshitaka

Abstract excerpt

OBJECTIVE: A previous large, randomized, control trial(JBR.10)revealed that adjuvant chemotherapy with cisplatin(CDDP) and vinorelbine(VNR)was effective for non-small-cell lung cancer(NSCLC). It was also reported that adjuvant chemotherapy was not effective for p53-negative or K-ras mutation-positive patients. To clarify whether p53 and ras statuses are true predictive markers for chemotherapy with cisplatin,...

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PMID: 22421763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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