Article
Androgen receptor acetylation sites differentially regulate gene control.
Journal of cellular biochemistry - 15 May 2008
Faus Hortensia, Haendler Bernard
Abstract excerpt
Androgen receptor (AR) function is modulated by post-translational modifications such as acetylation, ubiquitylation, sumoylation, and phosphorylation. Concerning acetylation, three lysines residues located in a consensus KxKK motif of the AR hinge domain have been identified. For a better evaluation of the role of this modification, the activity of AR modified at different acetylation sites was determined by...
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