Article
Multiple androgen response elements and a Myc consensus site in the androgen receptor (AR) coding region are involved in androgen-mediated up-regulation of AR messenger RNA.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 1999
Grad J M, Dai J L, Wu S, Burnstein K L
Abstract excerpt
The androgen receptor (AR) gene is transcriptionally regulated by AR (autoregulation); however, the androgen response elements (AREs) required for this process have not been found in the AR promoter or in the 5'-flanking region. We previously showed that the AR cDNA contains AREs involved in AR mRNA autoregulation and that auto(up)regulation is reproduced in PC3 cells (a human prostate cancer cell line)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.