Article
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.
PLoS genetics - 1 Apr 2011
Duncan Emma L, Danoy Patrick, Kemp John P, Leo Paul J, McCloskey Eugene, Nicholson Geoffrey C, Eastell Richard, Prince Richard L, Eisman John A, Jones Graeme, Sambrook Philip N, Reid Ian R, Dennison Elaine M, Wark John, Richards J Brent, Uitterlinden Andre G, Spector Tim D, Esapa Chris, Cox Roger D, Brown Steve D M, Thakker Rajesh V, Addison Kathryn A, Bradbury Linda A, Center Jacqueline R, Cooper Cyrus, Cremin Catherine, Estrada Karol, Felsenberg Dieter, Glüer Claus-C, Hadler Johanna, Henry Margaret J, Hofman Albert, Kotowicz Mark A, Makovey Joanna, Nguyen Sing C, Nguyen Tuan V, Pasco Julie A, Pryce Karena, Reid David M, Rivadeneira Fernando, Roux Christian, Stefansson Kari, Styrkarsdottir Unnur, Thorleifsson Gudmar, Tichawangana Rumbidzai, Evans David M, Brown Matthew A
Abstract excerpt
Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral density (BMD) is a major predisposing factor to fracture and is known to be highly heritable. Site-, gender-, and age-specific genetic effects on BMD are thought to be significant, but have largely not b...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.