Article
Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2021
Stürznickel Julian, Rolvien Tim, Delsmann Alena, Butscheidt Sebastian, Barvencik Florian, Mundlos Stefan, Schinke Thorsten, Kornak Uwe, Amling Michael, Oheim Ralf
Abstract excerpt
Reduced bone mineral density (BMD; ie, Z-score ≤-2.0) occurring at a young age (ie, premenopausal women and men <50 years) in the absence of secondary osteoporosis is considered early-onset osteoporosis (EOOP). Mutations affecting the WNT signaling pathway are of special interest because of their key role in bone mass regulation. Here, we analyzed the effects of relevant LRP5 and LRP6 variants on the clinical...
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