Article
Hetero- and homozygosity of MHC class II gene products in systemic lupus erythematosus. The Members of the Deutsche Multizentrische SLE-Studie.
Tissue antigens - 1 Oct 1991
Hartung K, Coldewey R, Krapf F, Lang B, Specker C, Schendel D, Schneider P, Seuchter S, Stangel W, Albert E
Abstract excerpt
An analysis of HLA class II antigens in 356 white patients with systemic lupus erythematosus (SLE) showed that all HLA-DR and -DQ homozygous and heterozygous combinations appear with frequencies expected from the observed gene frequencies. HLA-DR2 and HLA-DR3 gene frequencies were both increased...
Topics
- Alleles
- Autoimmune Diseases
- Disease Susceptibility
- Gene Frequency
- Genes, MHC Class II
- Genetic Predisposition to Disease
- Genotype
- HLA-D Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Humans
- Linkage Disequilibrium
- Lupus Erythematosus, Systemic