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Article

Alterations of the LPS determine virulence of Neisseria gonorrhoeae in guinea-pig subcutaneous chambers.

Microbial pathogenesis - 1 Sept 1991

Demarco de Hormaeche R, Macpherson A, Bowe F, Hormaeche C E

Abstract excerpt

The virulence of lipopolysaccharide (LPS) variants of Neisseria gonorrhoeae strain Gc40 was studied in vivo using the guinea-pig subcutaneous chamber model. Survival of variants D1, D2, D4 and D5 was assessed by viable counts made on chamber fluid at various times after inoculation. Chemotactic effect was measured by counts of white cells in the chambers. Differential cell counts and assessments of the location...

Topics

Animals
Antibody Formation
Chemotaxis, Leukocyte
Diffusion Chambers, Culture
Genetic Variation
Guinea Pigs
Lipopolysaccharides
Neisseria gonorrhoeae
Skin
Virulence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1800889
DOI: 10.1016/0882-4010(91)90046-d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1800889-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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