Increased sensitivity of gonococcal pilA mutants to bactericidal activity of normal human serum.

doi:10.1128/iai.61.11.4662-4668.1993

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Article

Increased sensitivity of gonococcal pilA mutants to bactericidal activity of normal human serum.

Infection and immunity - 1 Nov 1993

Taha M K

Abstract excerpt

PilA is a pleiotropic transcriptional regulator in Neisseria gonorrhoeae, encoded by an essential gene, pilA. It regulates pilin gene expression and stress response and it is implicated in gonococcal adaptation to external signals. All these phenomena may participate in gonococcal virulence. In this report, I tested the role of PilA in another aspect of gonococcal virulence, resistance to the bactericidal effect...

Topics

Alleles
Antigens, Bacterial
Bacterial Outer Membrane Proteins
Bacterial Proteins
Blood Bactericidal Activity
DNA-Binding Proteins
Fimbriae Proteins
Humans
Lipopolysaccharides
Mutation
Neisseria gonorrhoeae

Source

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Identifiers

PMID: 8406864
DOI: 10.1128/iai.61.11.4662-4668.1993
PMCID: PMC281218

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