Article
Heparin protects Opa+ Neisseria gonorrhoeae from the bactericidal action of normal human serum.
Infection and immunity - 1 May 1995
Chen T, Swanson J, Wilson J, Belland R J
Abstract excerpt
The pathobiological significance of lipooligosaccharide (LOS) and outer membrane opacity protein (Opa) changes in gonorrheal disease are poorly understood. We assessed variants of strain MS11mk with different LOS and Opa phenotypes for their liability to killing by normal human sera. LOS differences correlated with strikingly disparate susceptibilities to serum killing; LOSa variants were serum resistant, LOSb...
Topics
- Antigens, Bacterial
- Blood Bactericidal Activity
- Cytidine Monophosphate N-Acetylneuraminic Acid
- Genetic Variation
- Heparin
- Humans
- Lipopolysaccharides
- Neisseria gonorrhoeae
- Oligosaccharides