Article
Neisseria gonorrhoeae strain MS11 harbouring a mutation in gene aroA is attenuated and immunogenic.
Microbial pathogenesis - 1 Jul 1993
Chamberlain L M, Strugnell R, Dougan G, Hormaeche C E, Demarco de Hormaeche R
Abstract excerpt
An aroA mutant of gonococcal strain MS11 was constructed (JKD298) and compared with the wild-type (JKD288). The requirement of JKD298 for aromatic compounds, typical of an aroA mutant, was demonstrated using defined media. Other than the expected auxotrophy, no further differences could be demons...
Topics
- 3-Phosphoshikimate 1-Carboxyvinyltransferase
- Alkyl and Aryl Transferases
- Animals
- Antibodies, Bacterial
- Antibody Formation
- Bacterial Proteins
- Blood Bactericidal Activity
- Cytidine Monophosphate N-Acetylneuraminic Acid
- Diffusion Chambers, Culture
- Guinea Pigs
- Inflammation
- Lipopolysaccharides
- Mutagenesis, Insertional
- Mutation
- Neisseria gonorrhoeae
- Transferases
- Vaccines, Attenuated
- Virulence