Article
Protective role of Toll-like receptor 4 in experimental gonococcal infection of female mice.
Mucosal immunology - 1 Jan 2012
Packiam M, Wu H, Veit S J, Mavrogiorgos N, Jerse A E, Ingalls R R
Abstract excerpt
Neisseria gonorrhoeae is a common bacterial sexually transmitted infection. Like all Gram-negative bacteria, the outer membrane of the gonococcus is rich in endotoxin, a known ligand for Toll-like receptor (TLR)4. However, the role of endotoxin and that of its cognate receptor TLR4 in the mucosal response to acute gonococcal infection in the genital tract of women is unclear. To test this, we examined the course...
Topics
- Animals
- Cell Movement
- Cells, Cultured
- Cytokines
- Cytotoxicity, Immunologic
- Disease Models, Animal
- Female
- Gonorrhea
- Humans
- Inflammation Mediators
- Mice
- Mice, Inbred BALB C