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Article

Frequent Loss of Brm Expression in Gastric Cancer Correlates with Histologic Features and Differentiation State

15 Nov 2007

Abstract excerpt

The mammalian SWI/SNF chromatin remodeling complex, an essential epigenetic regulator, contains either a single Brm or BRG1 molecule as its catalytic subunit. We observed frequent loss of Brm expression but not of BRG1 in human gastric cancer cell lines. Treatment with histone deacetylase inhibitor rescued Brm expression, indicating epigenetic regulation of this gene, and an RNA interference-based colony...

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PMID: 18006815
DOI: 10.1158/0008-5472.can-07-2601

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