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Article

Treatment of Invasive Retinoblastoma in a Murine Model Using an Oncolytic Picornavirus

15 Nov 2007

Abstract excerpt

Retinoblastoma, the most common intraocular malignancy of childhood, metastasizes by initial invasion of the choroid and the optic nerve. There is no effective treatment for metastatic retinoblastoma, especially when the central nervous system (CNS) is involved, and prevention of this complication is a treatment priority. Seneca Valley Virus (SVV-001) is a conditionally replication-competent picornavirus that is...

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PMID: 18006805
DOI: 10.1158/0008-5472.can-07-2352

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